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Team

Petra Kluger

Prof. Dr. Petra Kluger

Sprechstunde während der Vorlesungszeit:

nach Vereinbarung

Gebäude 2
Raum 118
Tel. 07121 271-2061
Mail senden »

Lehrgebiete

Vorlesungen:

  • Humanbiologie
  • Praktikum Chemische Grundlagen der Biomedizin
  • Wissenschaftliches Arbeiten und Grundlagen der Biomedizin
  • Tissue Engineering
  • Immunologie
  • Biofabrication & Regenerative Medicine

Schwerpunkte:

  • Tissue Engineering
  • Zellmaterial-Interaktionen / Cell-material interaction
  • Biomaterialien, Oberflächenmodifikation / Biomaterials, surface modification
  • Zellbasierte in-vitro Testsysteme / Cell-based in vitro assays
Publikationen

Ausgewählte Publikationen finden Sie hier.

Vita

Berufliche Stationen

01/2019 - 12/2028

Assoziation an der Fakultät für Naturwissenschaften der Universität Hohenheim, Deutschland, mit dem Recht zur Verleihung des Doktorgrades (Dr. rer. nat.)

Since 09/2018 

Vizepräsidentin für Forschung der Hochschule Reutlingen, Deutschland

Since 11/2017

Professorin (W3) für Tissue Engineering und Biofabrikation an der Hochschule Reutlingen, Deutschland

11/2013 – 10/2017 

Shared-Professor (W3) für Tissue Engineering (49%) an der Hochschule Reutlingen, Deutschland

05/2013 – 10/2017

Leitung der Abteilung Zell- und Gewebetechnik (51%) am Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik (IGB) in Stuttgart, Deutschland

05/2009 – 04/2012

Stellvertretende Leitung der Abteilung Zell- und Tissue Engineering und Gruppenleitung am Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik (IGB) in Stuttgart, Deutschland

Aus- und Weiterbildung

08/2016 – 09/2016

DAAD-Kurzzeitdozentur (Stipendium) für die Lehre der Biofabrikation am Worcester Polytechnic Institute in Massachusetts, USA)

10/2010 – 10/2011 

Baden-Württembergisches Zertifikat für Hochschuldidaktik 150 h Fortbildung in verschiedenen Bereichen der Didaktik

07/2009

Promotionsprüfung an der Universität Stuttgart, Deutschland (summa cum laude)

05/2006 – 04/2009 

Promotionsstipendium der Peter und Traudl Engelhorn Stiftung

11/2007 – 11/2008

Postgraduales Fernstudium der Nanobiotechnologie an der Universität Kaiserslautern; Abschlussnote: "gut"

10/2000 – 04/2006

Studium der Technischen Biologie an der Universität Stuttgart, Abschlussnote: "ausgezeichnet".

Sonstige Funktionen

Intern

  • Prüfungsausschuss Bachelor Biomedizinische Wissenschaften
  • Prüfungsausschuss Master Biomedical Sciences
  • Mitglied der Studienkommission

Extern

  • Stellvertretende Vorsitzende der Deutschen Gesellschaft für Biomaterialien
  • Vorstandsmitglied der BioMedTech e.V.
  • Mitglied im Kuratorium des Naturwissenschaftlichen und Medizinischen Instituts an der Universität Tübingen

 

Professional experience

01/2019 - 12/2028

Association at the faculty of Natural Sciences at the University of Hohenheim, Germany with the right to award doctorates (Dr. rer. nat.)

Since 09/2018 

Vice-president at Reutlingen University, Germany

Since 11/2017

Full Professor (W3) for Tissue Engineering and Biofabrication at Reutlingen University, Germany

11/2013 – 10/2017 

Shared-Professor (W3) for Tissue Engineering (49%) at Reutlingen University, Germany

05/2013 – 10/2017

Head of the Department Cell and Tissue Engineering (51%) at the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) in Stuttgart, Germany

05/2009 – 04/2012

Deputy Head of the Department Cell and Tissue Engineering and group leader at the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) in Stuttgart, Germany

Education and Training

08/2016 – 09/2016

DAAD Short-term lectureship (Stipend) for teaching Biofabrication at Worcester Polytechnic Institute in Massachusetts, USA)

10/2010 – 10/2011 

Baden-Württemberg Certificate for University Didactic 150 h advanced training in various aspects of didactic

07/2009

Doctoral Examination passed with “summa cum laude” at the University of Stuttgart, Germany

05/2006 – 04/2009 

PhD-stipend from the Peter and Traudl Engelhorn foundation

11/2007 – 11/2008

Postgraduate distance study on Nanobiotechnology at the University of Kaiserslautern; final grade: “good“

10/2000 – 04/2006

Studies of Technical Biology at the University of Stuttgart, final grade: “excellent“

     

    Tobias Baldeweg

    M.Sc. Tobias Baldeweg

    Thematische Schwerpunkte:

    • Cultured meat/ Cellular Agriculture
    • Tissue Engineering
    • Serum-freie Zellkultur

    Gebäude 2
    Raum 007
    Tel. 07121 271-1458
    Mail senden »

    Publikationen

    Holsapple JS, Schnitzler L, Rusch L, Baldeweg TH, Neubert E, Kruss S, Erpenbeck L. Expansion microscopy of neutrophil nuclear structure and extracellular traps. Biophys Rep (N Y). 2022 Dec 10;3(1):100091. doi: 10.1016/j.bpr.2022.100091. PMID: 36619899; PMCID: PMC9813678.

    Vita

    2022-heute

    Promotion: Universität Hohenheim
    Thema: Entwicklung von FCS-freien Zellkulturmethoden und Scale-Up Optionen für Cultured Meat Forschung

    2020-2021

    Wissenschaftlicher Mitarbeiter: Medizinische Hochschule Hannover
    Thema: Ureter Differenzierung in der Embryonalentwicklung der Maus

    2018-2020

    Master: Molecular Medicine, Georg-August-Universität Göttingen
    Thema: Die Rolle von Ki-67 in der NETose

    2015-2018

    Bachelor: Molekulare Medizin, Georg-August-Universität Göttingen
    Thema: Validierung und Charakterisierung neuartiger, pathogener GRIA3 Mutationen als Auslöser für mentale Retardierung im Kindesalter

     

    2022-today

    PhD: University of Hohenheim
    Topic: Development of FCS-free culture methods and scale-up options for cultured meat research

    2020-2021

    Research Assistant: Medical School Hannover
    Topic: Ureter differentiation during embryonic development of the mouse

    2018-2020

    Master: Molecular Medicine, Georg-August-University Göttingen
    Topic: The role of Ki-67 in NETosis

    2015-2018

    Bachelor: Molecular Medicine, Georg-August-University Göttingen
    Topic: Validation and characterization of new, pathogenic GRIA3 mutations as triggers for mental retardation in childhood

    Franziska Albrecht

    M.Sc. Franziska Albrecht

    Thematische Schwerpunkte:

    • 3D Hydrogele
    • Biomaterialien
    • Zell-Material-Interaktion
    • Bioprinting
    • Humanes Fettgewebe

    Gebäude 2
    Raum 008
    Tel. 07121 271-1462
    Mail senden »

    Publikationen

    Scaffolds for Cultured Meat on the Basis of Polysaccharide Hydrogels Enriched with Plant-Based Protein
    Wollschlaeger JO, Maatz R, Albrecht FB, Klatt A, Heine S, Blaeser A, Kluger PJ. . Gels. 2022; 8(2):94.
    https://doi.org/10.3390/gels8020094

    Completely defined co-culture of adipogenic differentiated adipose-derived stem cells and microvascular endothelial cells
    Ann-Cathrin Volz, Larissa Hack, Franziska Atzinger, Petra J. Kluger
    ALTEX (2018) 35(4):464-476

    Vita

    2019 – heute

    Promotion: Ernährungswissenschaften, Universität Hohenheim
    Thema: Entwicklung und Testung eines mittels Bioprinting gefertigten, in vivo nahen 3D Fettgewebemodells basierend auf primären Zellen der humanen Subkutis

    2017 – 2019

    Master: Biomedical Sciences (Schwerpunkt Physiologie), Hochschule Reutlingen
    Thema: Establishment of an extrusion-based bioprinting process and GelMA bioink adaptation for the setup of 3D fatty tissue constructs

    2014 – 2017

    Bachelor: Biomedizinische Wissenschaften, Hochschule Reutlingen
    Thema: Entwicklung eines chemisch definierten, xenofreien Mediums für die Co-Kultur von humanen adipogen differenzierten Stammzellen aus dem Fettgewebe und mikrovaskulären Endothelzellen

    2019 – today

    PhD: Nutritional Sciences, University of Hohenheim, 
    Topic: Development and testing of a bioprinted, in vivo close-up 3D adipose tissue model based on primary cells of the human subcutis.

    2017 – 2019

    Master: Biomedical Sciences (Focus: Physiologie), Reutlingen University
    Topic: Establishment of an extrusion-based bioprinting process and GelMA bioink adaptation for the setup of 3D fatty tissue constructs

    2014 – 2017

    Bachelor: Biomedical Sciences, Reutlingen University
    Topic: Development of a chemically defined, xeno-free medium for the co-culture of human adipogenically differentiated stem cells from adipose tissue and microvascular endothelial cells.

    Simon Heine

    Dr. Simon Heine

    Thematische Schwerpunkte:

    • Co-culture systems
    • Cell-based test systems
    • Organ-on-a-chip
    • GC-MS analysis

    Gebäude 2
    Raum 008
    Tel. 07121 271-1441
    Mail senden »

    Publikationen

    Nellinger, S., Mrsic, I., Keller, S., Heine, S., Southan, A., Bach, M., Volz, A.-C., Chassé, T., & Kluger, P. J. (2022). Cell-derived and enzyme-based decellularized extracellular matrix exhibit compositional and structural differences that are relevant for its use as a biomaterial. Biotechnology and Bioengineering, 1– 15. https://doi.org/10.1002/bit.28047

    Wollschlaeger JO, Maatz R, Albrecht FB, Klatt A, Heine S, Blaeser A, Kluger PJ. Scaffolds for Cultured Meat on the Basis of Polysaccharide Hydrogels Enriched with Plant-Based Proteins. Gels. 2022; 8(2):94. https://doi.org/10.3390/gels8020094

    Heine, Simon; Kleih, Markus; Giménez, Neus; Böpple, Kathrin; Ott, German; Colomer, Dolors et al. (2018): Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA. In: Journal of hematology & oncology 11 (1), S. 112. DOI: 10.1186/s13045-018-0657-6.

    Höring, Elisabeth; Montraveta, Arnau; Heine, Simon; Kleih, Markus; Schaaf, Lea; Vöhringer, Matthias C. et al. (2017): Dual targeting of MCL1 and NOXA as effective strategy for treatment of mantle cell lymphoma. In: British journal of haematology 177 (4), S. 557–561. DOI: 10.1111/bjh.14571.

    Schaaf, Lea; Schwab, Matthias; Ulmer, Christoph; Heine, Simon; Mürdter, Thomas E.; Schmid, Jens O. et al. (2016): Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest. In: Cancer research 76 (10), S. 2868–2875. DOI: 10.1158/0008-5472.CAN-15-2908.

    Vita

    Since 06/2014

    PhD student at the Margarete Fischer-Bosch Institute of Clinical Pharmacology Stuttgart and University of Tübingen
     “Role of aberrant Cyclin D1-CDK4 activity apart from cell cycle in Mantle Cell Lymphoma and consequences for novel treatment options”

    09/2011 – 11/2014

    Pharmaceutical Biotechnology (M. Sc.), University of Applied Sciences Jena
    Master thesis: “Role of aberrant Cyclin D1-CDK4 activity apart from cell cycle in Mantle Cell Lymphoma and consequences for novel treatment options” at the Institute of Cell Biology and Immunology of the University of Stuttgart

    03/2008 – 08/2011

    Pharmaceutical Biotechnology (B. Sc.), University of Applied Sciences Biberach
    Bachelor thesis: “Establishing a production process on the basis of HEK293 suspension cells” at U3 Pharma GmbH München

    Projekte

    MicroLungDetect

    Anna Leikeim

    Dr. Anna Leikeim

    Gebäude 2
    Raum 008
    Tel. 07121 271-1509
    Mail senden »

    Publikationen

    A Preclinical Model of Cutaneous Melanoma Based on Reconstructed Human Epidermis

    Leikeim, A.*, Wußmann, M.*, Schmidt, F. F.*, Neto, N. G. B., Benz, F., Tiltmann, K., Junger, C., Monaghan, M. G., Schilling, B., Groeber-Becker, F. K.

    Scientific Reports, 2022

    https://doi.org/10.1038/s41598-022-19307-0

     

    3D printing of bioreactors in tissue engineering: A generalised approach

    Gensler M*, Leikeim A*, Möllmann M, Komma M, Heid S, Müller C, Boccaccini AR, Salehi S, Groeber-Becker F, Hansmann J.

    Plos One, 2020 

    https://doi.org/10.1371/journal.pone.0242615

     

    * contributed equally

    Vita

    Seit 2023

    PostDoc am Reutlingen Research Institute

    2016 – 2022

    Promotion: Life Sciences, Julius-Maximilians-Universität Würzburg

    Thema: Vaskularisierungsstrategien für Vollhautäquivalente zur Modellierung der Melanom-Progression

    2012 - 2015

    Master of Science: Zell- und Molekularbiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg

    Master-Thesis: Einfluss inflammatorischer Mediatoren auf den Glucosestoffwechsel von MSCs

    2009 – 2012

    Bachelor of Science: Molekulare Biotechnologie, Technische Universität München

    Bachelor-Thesis: Bestimmung verschiedener Interleukine im Blut von PRRSV-immunisierten Schweinen verschiedener Rassen

     

    Since 2023

    PostDoc at Reutlingen Research Institute

    2016 – 2022

    PhD: Life Sciences, Julius-Maximilians-Universität of Würzburg

    Topic: Vascularization Strategies for Full-Thickness Skin Equivalents to model Melanoma Progression

    2012 - 2015

    Master of Science: Cell and Molecular Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg

    Master Thesis: Influence of inflammatory mediators on the glucose metabolism of MSCs

    2009 – 2012

    Bachelor of Science: Molecular Biotechnology, Technical University of Munich

    Bachelor Thesis: Determination of different interleukins in the blood of PRRSV-immunised pigs of different breeds

    Lisa Penberthy

    M.Sc. Lisa Penberthy

    Thematische Schwerpunkte:

    • Extrusion-based Bioprinting
    • Tissue Engineering
    • Histology
    • Lab organization

    Gebäude 2
    Raum 009
    Tel. 07121 271-8199
    Mail senden »

    Vita
    Seit 03/2020

    Academic stuff member at Reutlingen Research Institute

    09/2016 – 07/2018:

    Biotechnology (M. Sc.), FH Aachen
    Master thesis: “Integration of electrospun membranes in microfluidic chip devices “at the Fraunhofer IGB, Stuttgart

    09/2012 – 08/2016:

    Biotechnology (B. Sc.), FH Aachen
    Bachelor thesis: “Evaluation and characterization of a novel PCL scaffold for cartilage tissue engineering “at the University Hospital Aachen

     

    Projekte
    • ImmuneFat2Skin
    • 6D-Biodruck
    Svenja Nellinger

    Dr. Svenja Nellinger

    Thematische Schwerpunkte:

    • Extrazelluläre Matrix
    • Zell-Material-Interaktion
    • Biomaterialien
    • Spektroskopische Zellcharakterisierung

    Gebäude 2
    Raum 011
    Tel. 07121 271-1492
    Mail senden »

    Publikationen

    Cell-derived and enzyme-based decellularized extracellular matrix exhibit compositional and structural differences that are relevant for its use as a biomaterial
    Nellinger, S., Mrsic, I., Keller, S., Heine, S., Southan, A., Bach, M., Volz, A.-C., Chassé, T., & Kluger, P. J. (2022).
    Biotechnology and Bioengineering, 1– 15.
    doi.org/10.1002/bit.28047

    Adipose stem cell-derived Extracellular Matrix represents a promising Biomaterial by inducing spontaneous formation of Prevascular-like Structures by MvECs
    Svenja Nellinger, Isabelle Schmidt, Simon Heine, Ann-Cathrin Volz and Petra J. Kluger
    Biotechnology and Bioengineering. 2020;1–13.
    DOI: 10.1002/bit.27481

    An Advanced “clickECM” that Can be Modified by the Inverse-Electron Demand Diels-Alder Reaction
    Svenja Nellinger, Mareike A. Rapp, Dr. Alexander Southan, Prof. Dr. Valentin Wittmann, Prof. Dr. Petra J. Kluger
    ChemBioChem. 2021
    https://doi.org/10.1002/cbic.202100266

    Generation of an azide-modified extracellular matrix by adipose-derived stem cells using metabolic glycoengineering
    Svenja Nellinger*, Silke Keller, Alexander Southan, Valentin Wittmann, Ann-Cathrin Volz and Petra J. Kluger
    Current Directions in Biomedical Engineering

    Cell-derived Extracellular Matrix as maintaining Biomaterial for adipogenic differentiation
    Svenja Nellinger, Simon Heine, Ann-Cathrin Volz and Petra J. Kluger*
    Current Directions in Biomedical Engineering
    doi.org/10.1515/cdbme-2020-3106

    Vita

    2016 – heute

    Promotion: Biologie, Universität Tübingen, Kooperatives Promotionskolleg Tübingen-Reutlingen, Thema: Hochdurchsatzerfassung von Zell-Material-Interaktion mittels Biomaterial Chip (an der Hochschule Reutlingen)

    2014 – 2016

    Master: Biologie (Schwerpunkt Physiologie), Universität Hohenheim, Thema: Completely defined adipogenic differentiation of adipose-derived stem cells and their validation as testing system (an der Hochschule Reutlingen)

    2010 – 2014

    Bachelor: Ernährungswissenschaften, Universität Hohenheim, Thema: Einfluss von Probiotika auf nicht-alkoholbedingte Fettlebererkrankungen

    2016 – today

    Promotion: Biology, University of Tübingen, Cooperative doctoral program Tübingen-Reutlingen, Topic: High-throughput detection of cell-material interaction using biomaterial chip. (at Reutlingen University)

    2014 – 2016

    Master: Biology (Focus Physiologie), University of Hohenheim, Topic: Completely defined adipogenic differentiation of adipose-derived stem cells and their validation as testing system (an der Hochschule Reutlingen)

    2010 – 2014

    Bachelor: Nutritional Sciences, University of Hohenheim, Topc: Influence of probiotics on non-alcoholic fatty liver disease.

    Projekte

    ViaZell 

    Sophia Nowakowski

    M.Sc. Sophia Nowakowski

    Thematische Schwerpunkte:

    • Haut Tissue Engineering
    • Zellkultur
    • Immunologie

    Gebäude 2
    Raum 007
    Tel. 07121 271-1448
    Mail senden »

    Publikationen

    Improvement of a three-layered in vitro skin model for topical application of irritating substances
    Freia Schmidt, Sophia Nowakowski, Petra J. Kluger
    Frontiers in Bioengineering and Biotechnology. 2020;1-11.
    doi: 10.3389/fbioe.2020.00388 

    Vita

    2021 – heute

    Promotion: 2021 – heute: Tissue Engineering, Universität Hohenheim, Thema: Ein humanes immunkompetentes 3-schichtiges Hautmodell als in vitro Testsystem (an der Hochschule Reutlingen)

    2019-2020:

    Industrie: Business Development Manager im Bereich Herz- und Lungenunterstützung, Medizintechnikunternehmen Heilbronn

    2017 – 2019

    Master: Biomedical Sciences, Hochschule Reutlingen, Thema: Improvement of a 3-layered in vitro skin model for topical application of irritating substances (an der Hochschule Reutlingen)

    2013 – 2017

    Bachelor: Biomedical Sciences, Reutlingen University, Topic: Establishment of an in vitro T cell receptor analysis system (at dkfz in Heidelberg)

    2021 – today

    PhD: Tissue Engineering, University of Hohenheim, Topic: A human immunocompetent 3-layer skin model as an in vitro test system. (at Reutlingen University)

    2019-2020

    Business Development Manager im Bereich Herz- und Lungenunterstützung, Medizintechnikunternehmen Heilbronn

    2017 – 2019

    Master: Biomedical Sciences, Reutlingen University, Topic: Improvement of a 3-layered in vitro skin model for topical application of irritating substances

    2013 – 2017

    Bachelor: Biomedizinische Wissenschaften, Hochschule Reutlingen, Thema: Establishment of an in vitro T cell receptor analysis system (am dkfz in Heidelberg)

    Projekte

    Immune-Fat2Skin

    Jannis Wollschläger

    M.Sc. Jannis Wollschläger

    Thematische Schwerpunkte:

    • Cultured meat/ Cellular Agriculture
    • Tissue Engineering
    • 3D Bioprinting

    Gebäude 2
    Raum 008
    Tel. 07121 271-1496
    Mail senden »

    Publikationen

    Wollschlaeger JO, Maatz R, Albrecht FB, Klatt A, Heine S, Blaeser A, Kluger PJ.
    Scaffolds for Cultured Meat on the Basis of Polysaccharide Hydrogels Enriched with Plant-Based Proteins. Gels. 2022; 8(2):94. https://doi.org/10.3390/gels8020094

    Vita

    Since 09/2019

    PhD student at the University of Hohenheim supervised by Prof. Dr. Petra Kluger and Prof. Dr. Melina Claussnitzer

    „Optimization of culture conditions for the defined differentiation, long-term and co-culture of adipose-derived stem cells for the setup of a fatty tissue model”

    04/2017 – 03/2019

    Industrial Biotechnology (M. Sc.), University of Applied Sciences Biberach/ Ulm University

    Master thesis: “Investigation of in-vitro test methods for release kinetics of bevacizumab and fluorescein isothiocyanate dextran from hydrogels or nanoparticles“ at the Institute for Applied Biotechnology of the University Biberach

    09/2013 – 03/2017

    Industrial Biotechnology (B. Sc.), University of Applied Sciences Biberach

    Bachelor thesis: “Investigation for solvent formations in Clostridium acetobutylicum“ at the Institute of Microbiology and Biotechnology of the University Ulm