Team
Prof. Dr. Petra Kluger
Sprechstunde während der Vorlesungszeit:
nach Vereinbarung
Gebäude 2
Raum 118
Tel. 07121 271-2061
Mail senden »- Lehrgebiete
Vorlesungen:
- Humanbiologie
- Praktikum Chemische Grundlagen der Biomedizin
- Wissenschaftliches Arbeiten und Grundlagen der Biomedizin
- Tissue Engineering
- Immunologie
- Biofabrication & Regenerative Medicine
Schwerpunkte:
- Tissue Engineering
- Zellmaterial-Interaktionen / Cell-material interaction
- Biomaterialien, Oberflächenmodifikation / Biomaterials, surface modification
- Zellbasierte in-vitro Testsysteme / Cell-based in vitro assays
- Publikationen
Ausgewählte Publikationen finden Sie hier.
- Vita
Berufliche Stationen
01/2019 - 12/2028 Assoziation an der Fakultät für Naturwissenschaften der Universität Hohenheim, Deutschland, mit dem Recht zur Verleihung des Doktorgrades (Dr. rer. nat.)
Since 09/2018
Vizepräsidentin für Forschung der Hochschule Reutlingen, Deutschland
Since 11/2017
Professorin (W3) für Tissue Engineering und Biofabrikation an der Hochschule Reutlingen, Deutschland
11/2013 – 10/2017
Shared-Professor (W3) für Tissue Engineering (49%) an der Hochschule Reutlingen, Deutschland
05/2013 – 10/2017
Leitung der Abteilung Zell- und Gewebetechnik (51%) am Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik (IGB) in Stuttgart, Deutschland
05/2009 – 04/2012
Stellvertretende Leitung der Abteilung Zell- und Tissue Engineering und Gruppenleitung am Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik (IGB) in Stuttgart, Deutschland
Aus- und Weiterbildung
08/2016 – 09/2016
DAAD-Kurzzeitdozentur (Stipendium) für die Lehre der Biofabrikation am Worcester Polytechnic Institute in Massachusetts, USA)
10/2010 – 10/2011
Baden-Württembergisches Zertifikat für Hochschuldidaktik 150 h Fortbildung in verschiedenen Bereichen der Didaktik
07/2009
Promotionsprüfung an der Universität Stuttgart, Deutschland (summa cum laude)
05/2006 – 04/2009
Promotionsstipendium der Peter und Traudl Engelhorn Stiftung
11/2007 – 11/2008
Postgraduales Fernstudium der Nanobiotechnologie an der Universität Kaiserslautern; Abschlussnote: "gut"
10/2000 – 04/2006
Studium der Technischen Biologie an der Universität Stuttgart, Abschlussnote: "ausgezeichnet".
Sonstige Funktionen
Intern
- Vizepräsidentin Forschung der Hochschule Reutlingen
- Prüfungsausschuss Bachelor Biomedizinische Wissenschaften
- Prüfungsausschuss Master Biomedical Sciences
- Mitglied der Studienkommission
Extern
- Stellvertretende Vorsitzende der Deutschen Gesellschaft für Biomaterialien
- Vorstandsmitglied der BioMedTech e.V.
- Mitglied im Kuratorium des Naturwissenschaftlichen und Medizinischen Instituts an der Universität Tübingen
Professional experience
01/2019 - 12/2028 Association at the faculty of Natural Sciences at the University of Hohenheim, Germany with the right to award doctorates (Dr. rer. nat.)
Since 09/2018
Vice-president at Reutlingen University, Germany
Since 11/2017
Full Professor (W3) for Tissue Engineering and Biofabrication at Reutlingen University, Germany
11/2013 – 10/2017
Shared-Professor (W3) for Tissue Engineering (49%) at Reutlingen University, Germany
05/2013 – 10/2017
Head of the Department Cell and Tissue Engineering (51%) at the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) in Stuttgart, Germany
05/2009 – 04/2012
Deputy Head of the Department Cell and Tissue Engineering and group leader at the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) in Stuttgart, Germany
Education and Training
08/2016 – 09/2016
DAAD Short-term lectureship (Stipend) for teaching Biofabrication at Worcester Polytechnic Institute in Massachusetts, USA)
10/2010 – 10/2011
Baden-Württemberg Certificate for University Didactic 150 h advanced training in various aspects of didactic
07/2009
Doctoral Examination passed with “summa cum laude” at the University of Stuttgart, Germany
05/2006 – 04/2009
PhD-stipend from the Peter and Traudl Engelhorn foundation
11/2007 – 11/2008
Postgraduate distance study on Nanobiotechnology at the University of Kaiserslautern; final grade: “good“
10/2000 – 04/2006
Studies of Technical Biology at the University of Stuttgart, final grade: “excellent“
M.Sc. Franziska Albrecht
Thematische Schwerpunkte:
- 3D Hydrogele
- Biomaterialien
- Zell-Material-Interaktion
- Bioprinting
- Humanes Fettgewebe
Gebäude 2
Raum 008
Tel. 07121 271-1462
Mail senden »- Publikationen
Scaffolds for Cultured Meat on the Basis of Polysaccharide Hydrogels Enriched with Plant-Based Protein
Wollschlaeger JO, Maatz R, Albrecht FB, Klatt A, Heine S, Blaeser A, Kluger PJ. . Gels. 2022; 8(2):94.
https://doi.org/10.3390/gels8020094Completely defined co-culture of adipogenic differentiated adipose-derived stem cells and microvascular endothelial cells
Ann-Cathrin Volz, Larissa Hack, Franziska Atzinger, Petra J. Kluger
ALTEX (2018) 35(4):464-476- Vita
2019 – heute
Promotion: Ernährungswissenschaften, Universität Hohenheim
Thema: Entwicklung und Testung eines mittels Bioprinting gefertigten, in vivo nahen 3D Fettgewebemodells basierend auf primären Zellen der humanen Subkutis2017 – 2019
Master: Biomedical Sciences (Schwerpunkt Physiologie), Hochschule Reutlingen
Thema: Establishment of an extrusion-based bioprinting process and GelMA bioink adaptation for the setup of 3D fatty tissue constructs2014 – 2017
Bachelor: Biomedizinische Wissenschaften, Hochschule Reutlingen
Thema: Entwicklung eines chemisch definierten, xenofreien Mediums für die Co-Kultur von humanen adipogen differenzierten Stammzellen aus dem Fettgewebe und mikrovaskulären Endothelzellen2019 – today
PhD: Nutritional Sciences, University of Hohenheim,
Topic: Development and testing of a bioprinted, in vivo close-up 3D adipose tissue model based on primary cells of the human subcutis.2017 – 2019
Master: Biomedical Sciences (Focus: Physiologie), Reutlingen University
Topic: Establishment of an extrusion-based bioprinting process and GelMA bioink adaptation for the setup of 3D fatty tissue constructs2014 – 2017
Bachelor: Biomedical Sciences, Reutlingen University
Topic: Development of a chemically defined, xeno-free medium for the co-culture of human adipogenically differentiated stem cells from adipose tissue and microvascular endothelial cells.
Dr. Simon Heine
Thematische Schwerpunkte:
- Co-culture systems
- Cell-based test systems
- Organ-on-a-chip
- GC-MS analysis
Gebäude 2
Raum 008
Tel. 07121 271-1441
Mail senden »- Publikationen
Nellinger, S., Mrsic, I., Keller, S., Heine, S., Southan, A., Bach, M., Volz, A.-C., Chassé, T., & Kluger, P. J. (2022). Cell-derived and enzyme-based decellularized extracellular matrix exhibit compositional and structural differences that are relevant for its use as a biomaterial. Biotechnology and Bioengineering, 1– 15. https://doi.org/10.1002/bit.28047
Wollschlaeger JO, Maatz R, Albrecht FB, Klatt A, Heine S, Blaeser A, Kluger PJ. Scaffolds for Cultured Meat on the Basis of Polysaccharide Hydrogels Enriched with Plant-Based Proteins. Gels. 2022; 8(2):94. https://doi.org/10.3390/gels8020094
Heine, Simon; Kleih, Markus; Giménez, Neus; Böpple, Kathrin; Ott, German; Colomer, Dolors et al. (2018): Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA. In: Journal of hematology & oncology 11 (1), S. 112. DOI: 10.1186/s13045-018-0657-6.
Höring, Elisabeth; Montraveta, Arnau; Heine, Simon; Kleih, Markus; Schaaf, Lea; Vöhringer, Matthias C. et al. (2017): Dual targeting of MCL1 and NOXA as effective strategy for treatment of mantle cell lymphoma. In: British journal of haematology 177 (4), S. 557–561. DOI: 10.1111/bjh.14571.
Schaaf, Lea; Schwab, Matthias; Ulmer, Christoph; Heine, Simon; Mürdter, Thomas E.; Schmid, Jens O. et al. (2016): Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest. In: Cancer research 76 (10), S. 2868–2875. DOI: 10.1158/0008-5472.CAN-15-2908.
- Vita
Since 06/2014
PhD student at the Margarete Fischer-Bosch Institute of Clinical Pharmacology Stuttgart and University of Tübingen
“Role of aberrant Cyclin D1-CDK4 activity apart from cell cycle in Mantle Cell Lymphoma and consequences for novel treatment options”09/2011 – 11/2014
Pharmaceutical Biotechnology (M. Sc.), University of Applied Sciences Jena
Master thesis: “Role of aberrant Cyclin D1-CDK4 activity apart from cell cycle in Mantle Cell Lymphoma and consequences for novel treatment options” at the Institute of Cell Biology and Immunology of the University of Stuttgart03/2008 – 08/2011
Pharmaceutical Biotechnology (B. Sc.), University of Applied Sciences Biberach
Bachelor thesis: “Establishing a production process on the basis of HEK293 suspension cells” at U3 Pharma GmbH München- Projekte
MicroLungDetect
Annemarie Klatt
Gebäude 2
Raum 006
Tel. 07121 271-1508
Mail senden »- Publikationen
Scaffolds for Cultured Meat on the Basis of Polysaccharide Hydrogels Enriched with Plant-Based Proteins
Wollschlaeger JO, Maatz R, Albrecht FB, Klatt A, Heine S, Blaeser A, Kluger PJ.
Gels. 2022; 8(2):94. https://doi.org/10.3390/gels8020094
M.Sc. Lisa Michalek
Thematische Schwerpunkte:
- Extrusion-based Bioprinting
- Tissue Engineering
- Histology
- Lab organization
Gebäude 2
Raum 009
Tel. 07121 271-8199
Mail senden »- Vita
Seit 03/2020 Academic stuff member at Reutlingen Research Institute
09/2016 – 07/2018:
Biotechnology (M. Sc.), FH Aachen
Master thesis: “Integration of electrospun membranes in microfluidic chip devices “at the Fraunhofer IGB, Stuttgart09/2012 – 08/2016:
Biotechnology (B. Sc.), FH Aachen
Bachelor thesis: “Evaluation and characterization of a novel PCL scaffold for cartilage tissue engineering “at the University Hospital Aachen- Projekte
- ImmuneFat2Skin
- 6D-Biodruck
Dr. Svenja Nellinger
Thematische Schwerpunkte:
- Extrazelluläre Matrix
- Zell-Material-Interaktion
- Biomaterialien
- Spektroskopische Zellcharakterisierung
Gebäude 2
Raum 011
Tel. 07121 271-1492
Mail senden »- Publikationen
Cell-derived and enzyme-based decellularized extracellular matrix exhibit compositional and structural differences that are relevant for its use as a biomaterial
Nellinger, S., Mrsic, I., Keller, S., Heine, S., Southan, A., Bach, M., Volz, A.-C., Chassé, T., & Kluger, P. J. (2022).
Biotechnology and Bioengineering, 1– 15.
doi.org/10.1002/bit.28047Adipose stem cell-derived Extracellular Matrix represents a promising Biomaterial by inducing spontaneous formation of Prevascular-like Structures by MvECs
Svenja Nellinger, Isabelle Schmidt, Simon Heine, Ann-Cathrin Volz and Petra J. Kluger
Biotechnology and Bioengineering. 2020;1–13.
DOI: 10.1002/bit.27481An Advanced “clickECM” that Can be Modified by the Inverse-Electron Demand Diels-Alder Reaction
Svenja Nellinger, Mareike A. Rapp, Dr. Alexander Southan, Prof. Dr. Valentin Wittmann, Prof. Dr. Petra J. Kluger
ChemBioChem. 2021
https://doi.org/10.1002/cbic.202100266Generation of an azide-modified extracellular matrix by adipose-derived stem cells using metabolic glycoengineering
Svenja Nellinger*, Silke Keller, Alexander Southan, Valentin Wittmann, Ann-Cathrin Volz and Petra J. Kluger
Current Directions in Biomedical EngineeringCell-derived Extracellular Matrix as maintaining Biomaterial for adipogenic differentiation
Svenja Nellinger, Simon Heine, Ann-Cathrin Volz and Petra J. Kluger*
Current Directions in Biomedical Engineering
doi.org/10.1515/cdbme-2020-3106- Vita
2016 – heute
Promotion: Biologie, Universität Tübingen, Kooperatives Promotionskolleg Tübingen-Reutlingen, Thema: Hochdurchsatzerfassung von Zell-Material-Interaktion mittels Biomaterial Chip (an der Hochschule Reutlingen)
2014 – 2016
Master: Biologie (Schwerpunkt Physiologie), Universität Hohenheim, Thema: Completely defined adipogenic differentiation of adipose-derived stem cells and their validation as testing system (an der Hochschule Reutlingen)
2010 – 2014
Bachelor: Ernährungswissenschaften, Universität Hohenheim, Thema: Einfluss von Probiotika auf nicht-alkoholbedingte Fettlebererkrankungen
2016 – today
Promotion: Biology, University of Tübingen, Cooperative doctoral program Tübingen-Reutlingen, Topic: High-throughput detection of cell-material interaction using biomaterial chip. (at Reutlingen University)
2014 – 2016
Master: Biology (Focus Physiologie), University of Hohenheim, Topic: Completely defined adipogenic differentiation of adipose-derived stem cells and their validation as testing system (an der Hochschule Reutlingen)
2010 – 2014
Bachelor: Nutritional Sciences, University of Hohenheim, Topc: Influence of probiotics on non-alcoholic fatty liver disease.
- Projekte
M.Sc. Sophia Nowakowski
Thematische Schwerpunkte:
- Haut Tissue Engineering
- Zellkultur
- Immunologie
Gebäude 2
Raum 007
Tel. 07121 271-1448
Mail senden »- Publikationen
Improvement of a three-layered in vitro skin model for topical application of irritating substances
Freia Schmidt, Sophia Nowakowski, Petra J. Kluger
Frontiers in Bioengineering and Biotechnology. 2020;1-11.
doi: 10.3389/fbioe.2020.00388- Vita
2021 – heute
Promotion: 2021 – heute: Tissue Engineering, Universität Hohenheim, Thema: Ein humanes immunkompetentes 3-schichtiges Hautmodell als in vitro Testsystem (an der Hochschule Reutlingen)
2019-2020:
Industrie: Business Development Manager im Bereich Herz- und Lungenunterstützung, Medizintechnikunternehmen Heilbronn
2017 – 2019
Master: Biomedical Sciences, Hochschule Reutlingen, Thema: Improvement of a 3-layered in vitro skin model for topical application of irritating substances (an der Hochschule Reutlingen)
2013 – 2017
Bachelor: Biomedical Sciences, Reutlingen University, Topic: Establishment of an in vitro T cell receptor analysis system (at dkfz in Heidelberg)
2021 – today
PhD: Tissue Engineering, University of Hohenheim, Topic: A human immunocompetent 3-layer skin model as an in vitro test system. (at Reutlingen University)
2019-2020
Business Development Manager im Bereich Herz- und Lungenunterstützung, Medizintechnikunternehmen Heilbronn
2017 – 2019
Master: Biomedical Sciences, Reutlingen University, Topic: Improvement of a 3-layered in vitro skin model for topical application of irritating substances
2013 – 2017
Bachelor: Biomedizinische Wissenschaften, Hochschule Reutlingen, Thema: Establishment of an in vitro T cell receptor analysis system (am dkfz in Heidelberg)
- Projekte
Immune-Fat2Skin
M.Sc. Freia Schmidt
Thematische Schwerpunkte:
- Haut Tissue Engineering
- Automatisierung im Tissue Engineering
- Cokultur Systeme
- Zellbasierte Testsysteme
- Melanom
Gebäude 2
Raum 006
Tel. 07121 271-1441
Mail senden »- Publikationen
- Schmid FF*, Kleinhans C*, Schmid FV, Kluger PJ: Comparison of osteoclastogenesis and resorption activity of human osteoclasts on tissue culture polystyrene and on natural extracellular bone matrix in 2D and 3D; Journal of Biotechnology. 2015
- Lotz C, Schmid FF, Rossi A, Kurdyn S, Kampik D, De Wever B, Walles H, Groeber FK:Alternative methods for the replacement of eye irritation testing; ALTEX. 2015
- Schmid FF, Schwarz T, Klos M, Schuberthan W, Walles H, Hansmann J, and Groeber FK: Applicability of a Dual-Arm Robotic System for Automated Downstream Analysis of Epidermal Models. Applied In Vitro Toxicology. 2016
- Groeber F, Engelhardt L, Lange J, Kurdyn S, Schmid FF, Rücker C, Mielke S, Walles H, Hansmann J:A first vascularized skin equivalent for as an alternative to animal experimentation; ALTEX. 2016
- Groeber F, Schober L, Schmid FF, Traube A, Kolbus-Hernandez S, Daton K, Hoffmann S, Petersohn S, Schäfer-Korting M, Walles H., Mewes :Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis (phase II), Toxicology in Vitro, Volume 36, 2016
- Lotz C*, Schmid FF*, Oechsle E, Monaghan MG, Walles H, Groeber-Becker F: Cross-linked Collagen Hydrogel Matrix Resisting Contraction To Facilitate Full-Thickness Skin Equivalents, ACS Applied Materials & Interfaces, 2017
- Rico Brendtke, Bart De Wever, Freia Schmid, Florian Groeber, Jan Hansmann, Heike Walles: High-Throughput Screening Techniques, in Alternatives for Dermal Toxicity Testing, C. Eskes, E. van Vliet, and H.I. Maibach, Editors. 2017, Springer International Publishing: Cham. p. 579-592.
- Schmid FV, Kleinhans C, Schmid FF, Kluger PJ: Osteoclast Formation within a Human Co-Culture System on Bone Material as an In Vitro Model for Bone Remodeling Processes; JMFK, 2018
- Schmid FF*, Grober-Becker F*, Schwab S, Thude S, Goebeler M, Walles H, Hansmann J: A standardized method based on pigmented epidermal models evaluates sensitivity against UV-irradiation; ALTEX, 2018
- Lotz C., Kiesewetter L., Schmid FF., Hansmann J., Walles H., Groeber-Becker F: Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation; Sci Rep, 2018
- Schmidt, F.F., S. Nowakowski, and P.J. Kluger, Improvement of a Three Layered in vitro Skin Model for Topical Application of Irritating Substances Front, Bioeng Biotechnol , 2020
*equally contributed
- Vita
Seit 08/2018
Reutlingen Research Institute
01/2015 – 06/2018:
Doktorandin an der Universität Würzburg betreut durch Prof. Dr. Heike Walles, Prof. Dr. Matthias Goebeler, Dr. Jan Hansmann und Dr. Florian Groeber-Becker
08/2017 – 06/2018
Wissenschaftliche Mitarbeiterin, Fraunhofer ISC, Würzburg
01/2013 – 08/2017
Wissenschaftliche Mitarbeiterin, Translational Center Würzburg ‚Regenerative therapies in oncology and musculoskeletal disease, Zweigstelle des Fraunhofer IGB, Würzburg
08/2013 – 12/2014
Wissenschaftliche Mitarbeiterin, Fraunhofer IGB, Stuttgart
09/2011 – 07/2013
Biomedical Engineering (M. Sc.), Hochschule Albstadt-Sigmaringen
Masterarbeit: “ Establishment of an osteoblast/osteoclast co-culture system to simulate the in vivo situation for testing iron-based bone replacement materials“ am Fraunhofer IGB, Abteilung CTE
03/2007 – 09/2011
Biotechnologie (B. Sc.), Hochschule Esslingen
Bachelorarbeit: “ Investigation of modified titanium substrates for endo-exo prostheses in terms of their interaction with human skin cells“ am Fraunhofer IGB, Abteilung CTE
Since 08/2018
Reutlingen Research Institute
01/2015 – 06/2018:
PhD student at the University of Würzburg supervised by Prof. Dr. Heike Walles, Prof. Dr. Matthias Goebeler, Dr. Jan Hansmann and Dr. Florian Groeber-Becker
08/2017 – 06/2018
Research Associate, Fraunhofer ISC, Würzburg
01/2013 – 08/2017
Research Associate, Translational Center Würzburg ‚Regenerative therapies in oncology and musculoskeletal disease, Branch of the Fraunhofer IGB, Würzburg
08/2013 – 12/2014
Research Associate, Fraunhofer IGB, Stuttgart
09/2011 – 07/2013
Biomedical Engineering (M. Sc.), University of Applied Sciences Albstadt-Sigmaringen
Master thesis: “ Establishment of an osteoblast/osteoclast co-culture system to simulate the in vivo situation for testing iron-based bone replacement materials“ at the Fraunhofer IGB, Department CTE
03/2007 – 09/2011
Biotechnologie (B. Sc.), University of Applied Sciences Esslingen
Bachelor thesis: “ Investigation of modified titanium substrates for endo-exo prostheses in terms of their interaction with human skin cells“ at the Fraunhofer IGB, Department CTE
- Projekte
- ImmuneFat2Skin
- 6D Druck
M.Sc. Jannis Wollschläger
Thematische Schwerpunkte:
- Cultured meat/ Cellular Agriculture
- Tissue Engineering
- 3D Bioprinting
Gebäude 2
Raum 008
Tel. 07121 271-1496
Mail senden »- Publikationen
Wollschlaeger JO, Maatz R, Albrecht FB, Klatt A, Heine S, Blaeser A, Kluger PJ.
Scaffolds for Cultured Meat on the Basis of Polysaccharide Hydrogels Enriched with Plant-Based Proteins. Gels. 2022; 8(2):94. https://doi.org/10.3390/gels8020094- Vita
Since 09/2019
PhD student at the University of Hohenheim supervised by Prof. Dr. Petra Kluger and Prof. Dr. Melina Claussnitzer
„Optimization of culture conditions for the defined differentiation, long-term and co-culture of adipose-derived stem cells for the setup of a fatty tissue model”
04/2017 – 03/2019
Industrial Biotechnology (M. Sc.), University of Applied Sciences Biberach/ Ulm University
Master thesis: “Investigation of in-vitro test methods for release kinetics of bevacizumab and fluorescein isothiocyanate dextran from hydrogels or nanoparticles“ at the Institute for Applied Biotechnology of the University Biberach
09/2013 – 03/2017
Industrial Biotechnology (B. Sc.), University of Applied Sciences Biberach
Bachelor thesis: “Investigation for solvent formations in Clostridium acetobutylicum“ at the Institute of Microbiology and Biotechnology of the University Ulm
