Smart Biomaterials and Biosystems

The research projects focus on the identification and validation of molecular biomarkers in neurodegenerative diseases.
The research projects focus on the identification and validation of molecular biomarkers in neurodegenerative diseases using multi-OMICS technologies. The identified biomarkers are then characterised in standardised cohorts, ultra-sensitive measurement methods for analysis are developed, and their subsequent use in pre-clinical and clinical studies is tested. In addition, molecular biological approaches are pursued in order to develop and apply personalised treatment concepts. 

Current research activities

• Ultra-sensitive measurement methods for protein-based target engagement biomarker measurement
• Protein reduction therapies for the treatment of monogenic diseases
• Influence of genetics on variable phenotypic disease expression
• Cross-species analysis of molecular biomarkers in longitudinal progression

The research projects focus on collagen-based biomaterials for regenerative medicine as well as (bio)polymers and their functional characterisation.
With regard to regulatory requirements, analytical methods for characterising physicochemical and biological properties are being developed and applied.

Current research activities

• Protein-based biomaterials for applications in regenerative medicine
• Enzyme immobilisation and carbon capture using biotechnological processes
• Drug delivery systems
• Correlative analysis of medical materials and surfaces to investigate and understand the relationship between biological reactions and material properties

Research projects at the NMI

• Collagen-based biomaterials and biochemical functionalization of collagen
• Active ingredient depot

Biosensor technology covers interdisciplinary, application-orientated issues from areas such as pharmaceutical screening, patient-related diagnostics and water analysis. The focus here is on the characterisation of biomolecular interactions and the quantification of biomarkers for diagnostics or trace substances in water.

The main areas of research include various optical transduction technologies, biological recognition structures, surface chemistry and assay development.
 

Fields of work

• Reflectometry & TIRF
• Immunoassays & receptor-based assays
• Characterisation of biomolecular interactions
• Diagnostics and drug screening

Molecular neurooncology is concerned with research into the molecular mechanisms underlying the development of tumours of the central nervous system, such as glioblastomas. The focus here is on genetic and epigenetic changes, signal transduction pathways and molecular biomarkers that are relevant for the diagnosis, prognosis and treatment of brain tumours.
Important fields of research in this area are the characterisation of oncogenic mutations, the investigation of the tumour microenvironment including the blood-brain barrier, the mechanisms of resistance to therapies and the development of targeted molecular therapeutic approaches. This includes research into new drugs, immunotherapeutic strategies and personalised approaches based on molecular tumour profiling.

Fields of work

• Genetic and epigenetic analyses
• Signal transduction pathways and tumour microenvironment
• Modelling of the blood-brain barrier
• Therapeutic approaches and biomarker development